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Phentermine: A Patient Guide

You might have heard about Phentermine from a friend who had used this product. Maybe some well-meaning coworker had suggested Phentermine to you as a solution to your weight problem. Probably you just come across Phentermine in the internet in your search for an effective diet pill.

Search no further. You have come to the right place if you want to know more about Phentermine. This page is all about Phentermine.

What is Phentermine?

Here are some quick facts about Phentermie:

  • Phentermine is a prescribed medication for short term treatment of obesity
  • Prescribed together with a diet and exercise program as well as behavior therapy
  • Approved by the Food and Drug Administration in 1959
  • Works by suppressing appetite
  • Brand names are Suprenza, Adipex, Zantryl, Oby-Cap and T-Diet
  • Available in tablets, capsules and resin capsules

Brief history

Phentermine was first approved by the Food and Drug administration in 1959 as a short term treatment for exogenous obesity. In 1959, only Phentermine resin was available in the United States and in 1970 Phentermine hydrochloride became available. Phentermine became popular partly due to its being significantly cheaper when compared to other diet pills in the market. In fact, in its heydays Phentermine accounted for half of the prescriptions for appetite suppressants.


When Phentermine was combined with other drugs that also treat obesity to form cocktail drugs, several setbacks occurred. Fen-Phen, a combination of Fenfluramine and Phentermine , had been an overnight sensation when a study made by Dr. Michael Weintraub and his colleagues of the University of Rochester cited Fen-Phen as a better treatment for obesity than diet and exercise. This is also true with another cocktail Dexfen-Phen, a combination of Dexfenfluramine and Phentermine. Dexfen-Phen also became popular for the treatment of obesity.

However, Fenfluramine and Dexfenfluramine had been implicated to cause heart valve disease and primary pulmonary hypertension, respectively. In 1997, the FDA requested the manufacturers of these two drugs to pull out these drugs from the marker amidst rising evidences of their involvement in such medical conditions.

Phentermine was never clearly connected to cause these diseases.

Dosage and administration

Dosage is individualized to get the maximum benefit at the lowest dosage possible

For normal adults not more than 60 years old, the normal dosage is 37.5 mg of Phentermine taken once daily before breakfast or 1 to 2 hours after breakfast

Phentermine hydrochloride is not recommended for treating obesity in children 16 years of age or younger.Taking Phentermine at night should be avoided as it cause insomnia.

How Phentermine works

Phentermine suppresses the appetite by stimulating the hypothalamus and affecting the release of catecholamines. The hypothalamus is an area of your brain that regulates certain bodily functions such as sleep and hunger among others. Catecholamines are neurotransmitters that give the body the so called fight or flight response. This response is so overwhelming that your hunger sensation is suppressed.

Side effects of Phentermine

Mild side effects

  • Headaches, tremors, dizziness
  • Restlessness or being hyperactive
  • Dry mouth or unpleasant taste in the mouth
  • Upset stomach, constipation or diarrhea
  • Insomnia

Severe mild effects

  • Unusual thoughts or behavior, confusion or irritability
  • Edema in ankles or legs
  • Very high blood pressure
  • Chest pains
  • Pounding heartbeats
  • Extreme happiness or sadness


Do not take Phentermine if you have the following :

  • History of heart disease
  • Glaucoma
  • Uncontrollable high blood pressure
  • Overactive thyroid
  • History of drug or alcohol abuse
  • If you are pregnant or breast feeding a child, avoid using Phentermine

Storage information

Keep Phentermine in its proper bottle or container

Avoid storing Phentermine where it can interact with heat, moisture and direct sunlight

Keep Phentermine and other medications out of reach of children